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BD 561963 PE Rat Anti-Mouse CD86 Clone GL1 (RUO)

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  • 商品货号 561963
  • 商品库存 10000
  • 上架时间: 2016-11-14
  • 商品重量 1克
  • 此商品可使用:500积分
  • 数量:
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 Brand

BD Pharmingen™
Alternative Name
B7-2; Ly-58; Cd28l2; Early T-cell costimulatory molecule 1; ETC1; MB7; CLS1
Concentration
0.2 mg/ml
Isotype
Rat LOU, also known as Louvain, LOU/C, LOU/M IgG2a, κ
Reactivity
Mouse (QC Testing) 
Application
Flow cytometry (Routinely Tested) 
Immunogen
Mouse (CBA/Ca) LPS-activated splenic B Cells
Storage Buffer
Aqueous buffered solution containing ≤0.09% sodium azide.
Regulatory Status

 

 

RUO

 

 

 

 

 

 

 

 

 

 

 

 

DESCRIPTION

 

The GL1 antibody has been reported to react with the B7-2 (CD86) costimulatory molecule expressed on a broad spectrum of leukocytes, including B lymphocytes, T lymphocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymphocytes.

 

 

 

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

 

FORMAT

Format
PE
Excitation Source
Blue 488 nm,Green 532 nm,Yellow/Green 561 nm
Excitation Max
496 nm
Emission Max
578 nm

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.

  • BD 561963 PE Rat Anti-Mouse CD86  Clone  GL1  (RUO)
    • 产品名称:BD 561963 PE Rat Anti-Mouse CD86 Clone GL1 (RUO)
    • 产品品牌:BD 561963 PE Rat Anti-Mouse CD86 Clone GL1 (RUO)
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BD 561963 PE Rat Anti-Mouse CD86  Clone  GL1  (RUO)
BD 561963 PE Rat Anti-Mouse CD86 Clone GL1 (RUO)

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