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BD 553347 PE Hamster Anti-Mouse CD61 Clone 2C9.G2 (also known as HMβ3-1) (RUO)

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  • 商品货号 553347
  • 商品库存 10000
  • 上架时间: 2016-11-14
  • 商品重量 1克
  • 此商品可使用:2600积分
  • 数量:
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 Brand:BD Pharmingen™

Alternative Name:Itgb3; Integrin beta-3; INGRB3; Platelet glycoprotein IIIa; GP3A; GPIIIa

Concentration
0.2 mg/ml
Isotype
Armenian Hamster IgG1, κ
Reactivity
Mouse (QC Testing)  Rat (Tested in Development) 
Application
Flow cytometry (Routinely Tested) 
Immunogen
Mouse T-cell Hybridoma 2B4 Vitronectin Receptor
Storage Buffer
Aqueous buffered solution containing ≤0.09% sodium azide.
Regulatory Status

 

 

RUO

 

 

 

 

 

 

 

 

 

 

 

DESCRIPTION

 

The 2C9.G2 antibody reacts with the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51) to form the vitronectin receptor and with the αIIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of αvβ3 integrin or vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the αvβ3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. Soluble and insoluble 2C9.G2 mAb mimics the effect of the natural ligands in smooth muscle cells from rat cremaster arterioles. Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to αvβ3. CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts. Cross-reactivity of mAb 2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis. mAb 2C9.G2 has been demonstrated to block binding of rat and mouse cells to fibronectin.

FORMAT

Format
PE
Excitation Source
Blue 488 nm,Green 532 nm,Yellow/Green 561 nm
Excitation Max
496 nm
Emission Max
578 nm

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.

  • BD 553347 PE Hamster Anti-Mouse CD61  Clone  2C9.G2 (also known as HMβ3-1) (RUO)
    • 产品名称:BD 553347 PE Hamster Anti-Mouse CD61 Clone 2C9.G2 (also known as HMβ3-1) (RUO)
    • 产品品牌:BD 553347 PE Hamster Anti-Mouse CD61 Clone 2C9.G2 (also known as HMβ3-1) (RUO)
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BD 553347 PE Hamster Anti-Mouse CD61  Clone  2C9.G2 (also known as HMβ3-1) (RUO)
BD 553347 PE Hamster Anti-Mouse CD61 Clone 2C9.G2 (also known as HMβ3-1) (RUO)

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