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BD 550274 Purified Rat Anti-Mouse CD31 Clone MEC 13.3(RUO)

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  • 商品货号 550274
  • 商品库存 10000
  • 上架时间: 2017-03-02
  • 商品重量 1克
  • 此商品可使用:1800积分
  • 规格:
    1ml
  • 数量:
     件
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  • 满意度 100%

 Brand

BD Pharmingen™
Alternative Name
PECAM-1
Concentration
15.625 µg/ml
Isotype
Rat LEW, also known as Lewis IgG2a, κ
Reactivity
Mouse (QC Testing) 
Application
Flow cytometry (Routinely Tested) 
Immunohistochemistry-frozen, Immunohistochemistry-zinc-fixed (Tested During Development) 
Immunoprecipitation, Blocking (Reported) 
Immunohistochemistry-formalin (antigen retrieval required) (Not Recommended) 
Immunogen
129/Sv mouse-derived endothelioma cell line tEnd.1
Entrez Gene ID
18613 
Storage Buffer
Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
Regulatory Status

RUO

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

DESCRIPTION

 

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is also expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the regulation of ligand specificity. CD38 and vitronectin receptor ( α v β 3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31.

 

 

FORMAT

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  • BD 550274 Purified Rat Anti-Mouse CD31 Clone MEC 13.3(RUO)
    • 产品名称:BD 550274 Purified Rat Anti-Mouse CD31 Clone MEC 13.3(RUO)
    • 产品品牌:BD 550274 Purified Rat Anti-Mouse CD31 Clone MEC 13.3(RUO)
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BD 550274 Purified Rat Anti-Mouse CD31 Clone MEC 13.3(RUO)
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